HCID 66995417, 화합물 → HCID 136368380, 화합물

HRID 1162414노트

반응식

HRID 1162414 반응식
[C:1]([C:3]1[CH:4]=[C:5]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][N:27]=2)[C:21]([O:23][CH3:24])=[O:22])[CH:6]=[C:7]([F:17])[C:8]=1[O:9]CC1C=CC=CC=1)#[N:2]>CO.C1COCC1.[C].[Pd]>[C:1]([C:3]1[CH:4]=[C:5]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][N:27]=2)[C:21]([O:23][CH3:24])=[O:22])[CH:6]=[C:7]([F:17])[C:8]=1[OH:9])#[N:2]

참가 물질

4

반응물 1

HCID 66995417HCID 66995417, 화합물

생성물 1

HCID 136368380HCID 136368380, 화합물

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 21899815MeOH tetrahydrofuran용매

실험 절차

Methyl 2-(3-cyano-4-benzyloxy-5-fluorophenyl)isonicotinate is stirred at room temperature in methanol-THF (1:1) under a hydrogen atmosphere at normal pressure in the presence of palladium-carbon to obtain methyl 2-(3-cyano-5-fluoro-4-hydroxyphenyl)isonicotinate. FN: 271.

출처 및 근거

ORD 기록
ord-adb2b66cc0e149a3b40867dfeb81b3e8
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07820700B2

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