Cyclopentylamine → Cyclopentylthiourea

HRID 1162555노트

반응식

[CH:1]1([NH2:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.C([N:24]=[C:25]=[S:26])(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O>>[CH:1]1([NH:6][C:25]([NH2:24])=[S:26])[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 2906Cyclopentylamine

HCID 4154759Fmoc isothiocyanate

생성물 1

HCID 736945Cyclopentylthiourea

실험 절차

Cyclopentyl-thiourea was prepared following procedure D using cyclopentyl amine (2.4 g, 28 mmol), and Fmoc-isothiocyanate (5.6 g, 20 mmol). Purification (Silica gel, ethyl acetate/hexane 1:1, 100%) provided the product (1.6 g) as white a solid. LCMS m/z: 145 (M+1)+.

후처리

customPurification (Silica gel, ethyl acetate/hexane 1:1, 100%)

출처 및 근거

ORD 기록: ord-91638c55f14d4de7ba3afd55bb9c1334
출처 데이터셋: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07820704B2

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