Methyl 1-benzyl-4-cyclopropylpyrrolidine-3-carboxylate → HCID 68646753, 화합물

HRID 1162724노트

반응식

HRID 1162724 반응식
[CH3:1][O:2][C:3]([CH:5]1[CH:9]([CH:10]2[CH2:12][CH2:11]2)[CH2:8][N:7](CC2C=CC=CC=2)[CH2:6]1)=[O:4]>CO.[Pd]>[CH3:1][O:2][C:3]([CH:5]1[CH:9]([CH:10]2[CH2:12][CH2:11]2)[CH2:8][NH:7][CH2:6]1)=[O:4]

참가 물질

4

반응물 1

HCID 68647670Methyl 1-benzyl-4-cyclopropylpyrrolidine-3-carboxylate

생성물 1

HCID 68646753HCID 68646753, 화합물수율 85.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

101.2 To a stirred solution of 1.13 g (3RS,4RS)-1-benzyl-4-cyclopropyl-pyrrolidine-3-carboxylic acid methyl ester at r.t. in 10 ml methanol under an argon atmosphere was added 113 mg 10% Pd/C. The mixture was then stirred at r.t. under a hydrogen atmosphere overnight. The catalyst was filtered off and rinsed with methanol. The filtrate was concentrated to leave 630 mg (3RS,4RS)-4-cyclopropyl-pyrrolidine-3-carboxylic acid methyl ester as a light yellow oil. MS170.3 ([M+H]+)

후처리

  1. filtrationThe catalyst was filtered off
  2. washrinsed with methanol
  3. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-326128ba9de0496c9db24ebe38b2f4e5
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07820699B2

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