(3-Trifluoromethyl-4,5,6,7-tetrahydroindazol-1-yl)-acetic acid tert-butyl ester → [3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetic acid

HRID 1162736

반응식

HRID 1162736 반응식
C([O:5][C:6](=[O:21])[CH2:7][N:8]1[C:16]2[CH2:15][CH2:14][CH2:13][CH2:12][C:11]=2[C:10]([C:17]([F:20])([F:19])[F:18])=[N:9]1)(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[F:20][C:17]([F:18])([F:19])[C:10]1[C:11]2[CH2:12][CH2:13][CH2:14][CH2:15][C:16]=2[N:8]([CH2:7][C:6]([OH:21])=[O:5])[N:9]=1

참가 물질

4

반응물 1

HCID 68647733(3-Trifluoromethyl-4,5,6,7-tetrahydroindazol-1-yl)-acetic acid tert-butyl ester

생성물 1

HCID 788039[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetic acid

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 6422Trifluoroacetic acid용매

실험 절차

(3-Trifluoromethyl-4,5,6,7-tetrahydroindazol-1-yl)-acetic acid tert-butyl ester was dissolved in a solution of DCM (30 mL) and TFA (30 mL), and the resulting mixture stirred at RT for 30 min, before concentration in vacuo to afford the title compound (4.50 g). This was used directly in the next step without any further purification.

출처 및 근거

ORD 기록
ord-348c038903f14f3dbdef867e442da7e8
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07820707B2

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