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Water → 4-(2,2-Dimethyl-propylamino)-6-{3-[4-(2-methoxy-ethyl)-piperazin-1-yl]-propoxy}-quinazoline-2-carbonitrile

HRID 1163002
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인쇄 미리보기

반응식

HRID 1163002 반응식
[CH3:1][C:2]([CH3:19])([CH3:18])[CH2:3][NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([OH:15])[CH:13]=2)[N:8]=[C:7]([C:16]#[N:17])[N:6]=1.Cl[CH2:21][CH2:22][CH2:23][N:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31]C)[CH2:26][CH2:25]1.[C:33](=O)([O-])[O-:34].[Cs+].[Cs+].O>CN(C=O)C>[CH3:1][C:2]([CH3:19])([CH3:18])[CH2:3][NH:4][C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH2:21][CH2:22][CH2:23][N:24]3[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][O:34][CH3:33])[CH2:26][CH2:25]3)[CH:13]=2)[N:8]=[C:7]([C:16]#[N:17])[N:6]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962Water2회HCID 10796Cesium carbonateHCID 612871081-(3-Chloro-propyl)4-propyl-piperazineHCID 686472384-(2,2-Dimethyl-propylamino)-6-hydroxy-quinazoline-2-carbonitrile

생성물 1

HCID 686477844-(2,2-Dimethyl-propylamino)-6-{3-[4-(2-methoxy-ethyl)-piperazin-1-yl]-propoxy}-quinazoline-2-carbonitrile

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

4-(2,2-Dimethyl-propylamino)-6-hydroxy-quinazoline-2-carbonitrile (0.3 mmol), 1-(3-chloro-propyl)-4-propyl-piperazine (0.62 mmol) and cesium carbonate (3.1 mmol) are stirred in DMF (3 ml) at RT for 20 hours. Water is added until a clear solution is formed. Then more water is added until the solution gets turbide. The precipitate formed is filtered off, washed with water and dried (vacuum). A powder with mp. 92-94° C., Rf=0.45 (CH2Cl2/MeOH=9:2) is obtained.

후처리

  1. customis formed
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. washwashed with water
  5. customdried (vacuum)
  6. customA powder with mp. 92-94° C., Rf=0.45 (CH2Cl2/MeOH=9:2) is obtained

출처 및 근거

ORD 기록
ord-936bc3e49e5341b6bf1d80a2dffccc14
출처 데이터셋
uspto-grants-2010_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07820818B2

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