HCID 57714115, 화합물 → HCID 57714122, 화합물

HRID 1163030노트

반응식

HRID 1163030 반응식
[CH3:1][C:2]([CH3:23])([CH3:22])[CH2:3][N:4]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]#[CH:21])=[CH:16][CH:15]=1)[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11]#[N:12])[N:6]=1>CCO.[Pd]>[CH3:1][C:2]([CH3:22])([CH3:23])[CH2:3][N:4]([CH2:13][C:14]1[CH:15]=[CH:16][C:17]([CH2:20][CH3:21])=[CH:18][CH:19]=1)[C:5]1[CH:10]=[CH:9][N:8]=[C:7]([C:11]#[N:12])[N:6]=1

참가 물질

4

반응물 1

HCID 57714115HCID 57714115, 화합물

생성물 1

HCID 57714122HCID 57714122, 화합물수율 112%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

4-[(2,2-Dimethyl-propyl)-(4-ethynyl-benzyl)-amino]-pyrimidine-2-carbonitrile (47 mg, 0.11 mmoles) is dissolved in 5 ml of EtOH and 10% Pd—C (5 mg) is added at rt. The mixture is stirred under hydrogen at rt for overnight and is filtered through a pad of Celite which is washed with EtOH. The filtrate is concentrated and the crude product is purified by silica gel column chromatography to give 38 mg of desired 4-[(2,2-dimethyl-propyl)-(4-ethyl-benzyl)-amino]-pyrimidine-2-carbonitrile in 77% yield.

후처리

  1. filtrationis filtered through a pad of Celite which
  2. washis washed with EtOH
  3. concentrationThe filtrate is concentrated
  4. customthe crude product is purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-e7eba47d717740a1a29999279891b557
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07820818B2

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