Levulinic Acid → 9-Methoxy-11b-methyl-1,2,5,6,11,11b-hexahydro-indolizino[8,7-b]indol-3-one

HRID 1163081

반응식

HRID 1163081 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:12](=[CH:13][CH:14]=1)[C:8]([CH2:9][CH2:10][NH2:11])=[CH:7][NH:6]2.[C:15](O)(=[O:21])[CH2:16][CH2:17][C:18]([CH3:20])=O>C(OC(O)C)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:12]([C:8]3[CH2:9][CH2:10][N:11]4[C:18]([CH3:20])([CH2:17][CH2:16][C:15]4=[O:21])[C:7]=3[NH:6]2)=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 11579Levulinic AcidHCID 176542-(2-Aminoethyl)-5-methoxyindole

생성물 1

HCID 589707669-Methoxy-11b-methyl-1,2,5,6,11,11b-hexahydro-indolizino[8,7-b]indol-3-one수율 71.8%

시약·촉매·용매 1

HCID 101298981-Ethoxyethanol용매

실험 절차

A mixture of 6-methoxytryptamine (0.95 g, 5 mmol) and levulinic acid (0.7 g, 6 mmol) in ethoxyethanol is heated at ruflux temperature for 16 hours, cooled to room temperature and concentrated in vacuo to give 9-methoxy-11b-methyl-1,2,5,6,11,11b-hexahydro-indolizino[8,7-b]indol-3-one (0.97 g) identified by NMR, HPLC and MS [271.2 m/e (M+H)].

후처리

  1. temperatureis heated at ruflux temperature for 16 hours
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-d1b0d087b438454ba17e4ca35b4036b7
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07820825B2

연결된 노트

불러오는 중…