1-Methylpiperidine-4-carbonyl chloride → 1-methylpiperidine-4-carboxylic acid (6-amino-1H-indazol-3-yl)-amide

반응식

[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8](Cl)=[O:9])[CH2:4][CH2:3]1.[NH2:11][C:12]1[C:20]2[C:15](=[CH:16][C:17]([NH2:21])=[CH:18][CH:19]=2)[NH:14][N:13]=1>>[NH2:21][C:17]1[CH:16]=[C:15]2[C:20]([C:12]([NH:11][C:8]([CH:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]3)=[O:9])=[N:13][NH:14]2)=[CH:19][CH:18]=1

참가 물질

반응물 2

HCID 4365031-Methylpiperidine-4-carbonyl chloride

HCID 534153661H-Indazole-3,6-diamine

생성물 1

HCID 684458371-methylpiperidine-4-carboxylic acid (6-amino-1H-indazol-3-yl)-amide

실험 절차

1-Methylpiperidine-4-carbonyl chloride (1 mmol), prepared from its corresponding carboxylic acid using general procedure E, was reacted with 3,6-diaminoindazole (1 mmol) (see Example 69) employing general procedure E to yield 1-methylpiperidine-4-carboxylic acid (6-amino-1H-indazol-3-yl)-amide.

출처 및 근거

ORD 기록: ord-19d131e0041a44389c41e768012782b8
출처 데이터셋: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07820821B2

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