Water → 2-bromo-1-(1H-indazol-6-yl)ethan-1-one
반응식
C1CNC(=O)C1.[Br:7][Br-]Br.[NH:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:19](=[O:21])[CH3:20])[CH:17]=2)[CH:12]=[N:11]1.O>C1COCC1>[Br:7][CH2:20][C:19]([C:16]1[CH:17]=[C:18]2[C:13]([CH:12]=[N:11][NH:10]2)=[CH:14][CH:15]=1)=[O:21]참가 물질
4
실험 절차
Pyrrolidone hydrotribromide (1.8 g, 3.6 mmol) was added to a solution of 1-(1H-indazol-6-yl)ethanone (0.5 g, 3 mmol) in THF (10 mL) and the solution was heated at reflux for 2 h. The solution was allowed to cool to room temperature and H2O (30 mL) was added and the mixture was extracted with EtOAc (3×20 mL) and dried (MgSO4). The solvent was removed at reduced pressure to afford 2-bromo-1-(1H-indazol-6-yl)-ethanone, which was used directly in the next step with no purification.
후처리
- temperaturethe solution was heated
- temperatureat reflux for 2 h
- extractionthe mixture was extracted with EtOAc (3×20 mL)
- dry with materialdried (MgSO4)
- customThe solvent was removed at reduced pressure
출처 및 근거
- ORD 기록
- ord-63c0f71bdaf4490e87f0e85d06ee18fa
- 출처 데이터셋
- uspto-grants-2010_10
- 특허 번호
- US07820821B2
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