Ethyl bromopyruvate → N-[4-(Ethoxycarbonyl)-1,3-thiazol-2-yl]hexopyranosylamine--hydrogen bromide (1/1)

HRID 1163877노트

반응식

HRID 1163877 반응식
[Br:1][CH2:2][C:3](=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C@@H:10]1([NH:21][C:22]([NH2:24])=[S:23])[O:18][C@H:17]([CH2:19][OH:20])[C@@H:15]([OH:16])[C@H:13]([OH:14])[C@H:11]1[OH:12]>C(O)C>[BrH:1].[C@@H:10]1([NH:21][C:22]2[S:23][CH:2]=[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[N:24]=2)[O:18][C@H:17]([CH2:19][OH:20])[C@@H:15]([OH:16])[C@H:13]([OH:14])[C@H:11]1[OH:12]

참가 물질

4

반응물 2

HCID 66144Ethyl bromopyruvateHCID 2728946Thiourea, beta-D-glucopyranosyl-

생성물 1

HCID 157591N-[4-(Ethoxycarbonyl)-1,3-thiazol-2-yl]hexopyranosylamine--hydrogen bromide (1/1)

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl bromopyruvate (8.99 g., 0.047 mole) was added to a suspension of N-β-D-glucopyranosylthiourea (10 g., 0.042 mole) in 120 ml. of hot ethanol, and the reaction was completed by heating 30 minutes. During the heating, the mixture became a clear solution. The reaction solution was evaporated to dryness in vacuo. The residue was crystallized from ethanol and acetone, filtered, and dried at room temperature in vacuo, yielding 16.03 g. (91.9%); white powder; m.p. 162°-163°(dec.).

후처리

  1. temperatureby heating 30 minutes
  2. customThe reaction solution was evaporated to dryness in vacuo
  3. customThe residue was crystallized from ethanol and acetone
  4. filtrationfiltered
  5. customdried at room temperature in vacuo
  6. customyielding 16.03 g

출처 및 근거

ORD 기록
ord-7eca43226cbf4680be77ee7ecbcefe63
출처 데이터셋
uspto-grants-1983_01
특허 번호
US04367226

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