Toluene → HCID 131712929, 화합물

HRID 1163911노트

반응식

HRID 1163911 반응식
[CH2:1]([NH:5][CH2:6][CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)[CH2:2][CH2:3][CH3:4].[CH3:17][N:18]([C:23]([O:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[O:24])[CH:19]([CH3:22])C=O.[C:33]1(C)C=CC=CC=1>>[CH2:1]([N:5]1[CH:6]=[CH:7][C:8]2[C:9]([N:10]=[C:11]3[C:16]=2[CH:15]=[CH:14][CH:13]=[CH:12]3)=[CH:17]1)[CH2:2][CH2:3][CH3:4].[CH3:17][N:18]([CH2:19][CH2:22][C:33]1[N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[CH:6]=[CH:7][C:8]2[C:9]=1[N:10]=[C:11]1[C:16]=2[CH:15]=[CH:14][CH:13]=[CH:12]1)[C:23]([O:25][CH2:26][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1)=[O:24]

참가 물질

5

반응물 3

HCID 1140TolueneHCID 45582N-Butyl-1H-indole-3-ethanamineHCID 20513196HCID 20513196, 화합물

생성물 2

HCID 131712929HCID 131712929, 화합물HCID 131712930HCID 131712930, 화합물

실험 절차

To a solution of 3.4 g of N-n-butyl-tryptamine in 50 ml of toluene are added 4.6 g of N-methyl-N-benzyloxycarbonyl-2-aminopropionaldehyde, and the mixture is refluxed for 15 hours. After the reaction, the mixture is condensed under reduced pressure. Then, the residue obtained is purified by silica gel chromatography. 3.9 g of 1,2,3,4-tetrahydro-1-(2-N-methyl-N-benzyloxycarbonylamino)ethyl)-2-n-butyl-β-carboline (cis isomer) and 1.32 g of 1,2,3,4-tetrahydro-1-(2-(N-methyl-N-benzyloxycarbonylamino)ethyl-2-n-butyl-β-carboline (trans isomer) are obtained, respectively.

후처리

  1. temperaturethe mixture is refluxed for 15 hours
  2. customAfter the reaction
  3. customcondensed under reduced pressure
  4. customThen, the residue obtained
  5. customis purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-b3e85bcbf88e47baa43e6bc954019c97
출처 데이터셋
uspto-grants-1983_01
특허 번호
US04367230

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