Hydrazine → HCID 54187452, 화합물

HRID 11640

반응식

HRID 11640 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:20][CH2:21][C:22]([N:24]2[CH2:29][C@H:28]([CH3:30])[N:27]([CH2:31][C:32]3[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=3)[CH2:26][C@H:25]2[CH3:39])=[O:23])=[C:6]([CH:19]=1)[CH2:7][N:8]1C(=O)C2C(=CC=CC=2)C1=O.NN>C(O)C>[NH2:8][CH2:7][C:6]1[CH:19]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[O:20][CH2:21][C:22]([N:24]1[CH2:29][C@H:28]([CH3:30])[N:27]([CH2:31][C:32]2[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=2)[CH2:26][C@H:25]1[CH3:39])=[O:23]

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 696554042-(5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzyl)-isoindole-1,3-dione

생성물 1

HCID 54187452HCID 54187452, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 2-(5-chloro-2-{2-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-2-oxo-ethoxy}-benzyl)-isoindole-1,3-dione (0.87 g, 1.59 mmol) in ethanol (20 mL) was added 35% hydrazine (3 mL, 33.1 mmol). After 17 hours, the reaction was filtered and concentrated to a tan solid. This solid was triturated with methylene chloride and the title compound was obtained after filtration, drying over magnesium sulfate and concentrating in vacuo (0.62 g).

후처리

  1. filtrationthe reaction was filtered
  2. concentrationconcentrated to a tan solid
  3. customThis solid was triturated with methylene chloride

출처 및 근거

ORD 기록
ord-3e772f25c01b4b32b32b3bd235b01aab
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098212B2

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