Allyl bromide → 2-(2-Chlorophenylthio)-6-allylphenol

HRID 1164075노트

반응식

HRID 1164075 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[OH:15].[CH2:16](Br)[CH:17]=[CH2:18].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C(C)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([CH2:18][CH:17]=[CH2:16])[C:10]=1[OH:15]

참가 물질

5

반응물 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 205134692-(2-Chlorophenylthio)phenol

생성물 1

HCID 130666682-(2-Chlorophenylthio)-6-allylphenol수율 83.5%

시약·촉매·용매 1

HCID 7909Methyl Isobutyl Ketone용매

실험 절차

A mixture of 2-(2-chlorophenylthio)phenol (33 g), allyl bromide (25 g) and dried potassium carbonate (29 g) in methyl isobutyl ketone (200 ml) was refluxed under heating for 1.5 hours. After cooling to the ambient temperature, the reaction mixture was filtered, and the filtrate was evaporated under reduced pressure. The resultant oily residue was stirred at 230° C. for 3 hours and then distilled under reduced pressure to give oily 2-(2-chlorophenylthio)-6-allylphenol (32.2 g) bp 157°-162° C./0.7 mmHg.

후처리

  1. temperaturewas refluxed
  2. temperatureunder heating for 1.5 hours
  3. filtrationthe reaction mixture was filtered
  4. customthe filtrate was evaporated under reduced pressure
  5. distillationdistilled under reduced pressure

출처 및 근거

ORD 기록
ord-e1215f4f06b9471583ca78ed7edf3cc8
출처 데이터셋
uspto-grants-1983_01
특허 번호
US04367238

반응 노트

불러오는 중…