Thionyl Chloride → 2-Chlorophenyl 2-methoxy-3-chloromethylphenyl thioether

HRID 1164080노트

반응식

HRID 1164080 반응식
[CH3:1][O:2][C:3]1[C:10]([S:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]O.S(Cl)([Cl:21])=O>N1C=CC=CC=1.C1C=CC=CC=1>[CH3:1][O:2][C:3]1[C:4]([CH2:5][Cl:21])=[CH:7][CH:8]=[CH:9][C:10]=1[S:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:18]

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 53999561HCID 53999561, 화합물

생성물 1

HCID 205134642-Chlorophenyl 2-methoxy-3-chloromethylphenyl thioether

시약·촉매·용매 2

HCID 1049Pyridine촉매HCID 241Benzene용매

실험 절차

A mixture of 2-methoxy-3-(2-chlorophenylthio)benzyl alcohol (9 g), thionyl chloride (4.6 ml) and pyridine (3 drops) in dried benzene (60 ml) was refluxed under heating for 30 minutes. The reaction mixture was cooled to the ambient temperature and evaporated under reduced pressure. The residue was dissolved in diethyl ether, and the solution was washed with water, saturated aqueous sodium bicarbonate and water in turn, dried over magnesium sulfate and then evaporated under reduced pressure to give oily 2-chlorophenyl 2-methoxy-3-chloromethylphenyl thioether (9.2 g).

후처리

  1. temperaturewas refluxed
  2. temperatureunder heating for 30 minutes
  3. customevaporated under reduced pressure
  4. dissolutionThe residue was dissolved in diethyl ether
  5. washthe solution was washed with water, saturated aqueous sodium bicarbonate and water in turn
  6. dry with materialdried over magnesium sulfate
  7. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-ee3ee6d3e94e4c04bc8dd8a29e34a833
출처 데이터셋
uspto-grants-1983_01
특허 번호
US04367238

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