Water → HCID 20513473, 화합물

HRID 1164082노트

반응식

HRID 1164082 반응식
[CH3:1][O:2][C:3]1[C:8]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:17][C:18]#N.[OH-:20].[K+].[OH2:22]>C(O)C>[CH3:1][O:2][C:3]1[C:8]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:17][C:18]([OH:22])=[O:20]

참가 물질

5

반응물 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 205134652-[2-Methoxy-3-(2-chlorophenylthio)phenyl]acetonitrile

생성물 1

HCID 20513473HCID 20513473, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2-[2-methoxy-3-(2-chlorophenylthio)phenyl]acetonitrile (1.5 g) and potassium hydroxide (870 mg) in ethanol (40 ml) and water (20 ml) was refluxed under heating for 24 hours. The reaction mixture was evaporated under reduced pressure and the residue was dissolved in water. The aqueous solution was washed with diethyl ether, acidified with dil. hydrochloric acid and extracted with diethyl ether. The extract was washed with water, dried and then evaporated to give oily 2-[2-methoxy-3-(2-chlorophenylthio)phenyl]acetic acid (1.4 g).

후처리

  1. temperaturewas refluxed
  2. temperatureunder heating for 24 hours
  3. customThe reaction mixture was evaporated under reduced pressure
  4. dissolutionthe residue was dissolved in water
  5. washThe aqueous solution was washed with diethyl ether
  6. extractionextracted with diethyl ether
  7. washThe extract was washed with water
  8. customdried
  9. customevaporated

출처 및 근거

ORD 기록
ord-a142a796e3684adfb481e70a1fcce0d7
출처 데이터셋
uspto-grants-1983_01
특허 번호
US04367238

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