2(1H)-Pyrimidinone, 4-amino-1-arabinofuranosyl- → HCID 13090283, 화합물

HRID 1164145

반응식

HRID 1164145 반응식
[CH:1]1([N:10]2[CH:17]=[CH:16][C:14]([NH2:15])=[N:13][C:11]2=[O:12])[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]1[OH:3].C(=O)([O-])O.[Na+].[CH2:23]([O:32][C:33](Cl)=[O:34])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31]>CC(N(C)C)=O>[CH2:23]([O:32][C:33]([NH:15][C:14]1[CH:16]=[CH:17][N:10]([C@@H:1]2[O:7][C@H:6]([CH2:8][OH:9])[C@@H:4]([OH:5])[C@@H:2]2[OH:3])[C:11](=[O:12])[N:13]=1)=[O:34])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31]

참가 물질

5

반응물 3

HCID 1146822(1H)-Pyrimidinone, 4-amino-1-arabinofuranosyl-HCID 516892Sodium BicarbonateHCID 544663Nonyl Chloroformate

생성물 1

HCID 13090283HCID 13090283, 화합물수율 37.3%

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

반응 조건

온도
22.5 °C

실험 절차

In 120 ml of dimethylacetamide, 6.0 g of arabinofuranosylcytosine is dissolved and to the resultant solution are added 4.15 g of sodium hydrogen carbonate and 7.66 g of nonyloxycarbonyl chloride. The mixture is then allowed to react under stirring at 20 to 25° C. for 2 hours. After the reaction, the solvent is removed under reduced pressure and the residue is dissolved in a small amount of ethanol. Water is then added to the resultant solution and the precipitated solids are collected by filtration, followed by drying. The white powders obtained are washed thoroughly with ethyl ether to obtain 3.8 g of N4 -nonyloxycarbonyl-1-β-D-arabinofuranosylcytosine (Yield:37%).

후처리

  1. customto react
  2. customAfter the reaction
  3. customthe solvent is removed under reduced pressure
  4. dissolutionthe residue is dissolved in a small amount of ethanol
  5. additionWater is then added to the resultant solution
  6. filtrationthe precipitated solids are collected by filtration
  7. customby drying
  8. customThe white powders obtained
  9. washare washed thoroughly with ethyl ether

출처 및 근거

ORD 기록
ord-7e063a2917d149f8967e02cab15a0838
출처 데이터셋
uspto-grants-1983_01
특허 번호
US04367332

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