Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 3-Methoxy-1,2,4,5-tetramethylbenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | 2,3,5,6-Tetramethylphenol | HCID 10694 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 3-Methoxy-1,2,4,5-tetramethylbenzene | HCID 278664 | — |
반응 단계
In 150 ml of DMSO were dissolved 15.0 g of 2,3,5,6-tetramethylphenol and 28 ml of methyl iodide. Under ice-cooling 6.3 g of 60% sodium hydride in oil was added, and the mixture was stirred at room temperature for 1 hour. The excess sodium hydride was decomposed with MeOH and after addition of water extraction with ether was carried out. The extract was dried over sodium sulfate. Removal of the solvent by distillation leaves crystals which were recrystallized from MeOH.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04368150 |
| 출처 데이터셋 | uspto-grants-1983_01 |
| ORD ID | ord-655501f6e8924ea0b35aba1e4c8912f1 |
| 출처 메모 | uspto-grants-1983_01 |