Methane → Sodium 3-methoxy-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate
반응식
[CH3:1][O:2][C:3]1[CH2:9][CH:8]2[N:5]([C:6](=[O:10])[CH2:7]2)[C:4]=1[C:11]([O:13]CC1C=CC=CC=1)=[O:12].C.C(=O)(O)[O-].[Na+:26]>[Pd].O1CCOCC1.O>[CH3:1][O:2][C:3]1[CH2:9][CH:8]2[N:5]([C:6](=[O:10])[CH2:7]2)[C:4]=1[C:11]([O-:13])=[O:12].[Na+:26]참가 물질
6
실험 절차
A mixture of benzyl 3-methoxy-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate (50 mg) and 10% palladium on powdered charcoal (50 mg) in 1:1 dioxane-H2O (5 ml) containing sodium bicarbonate (12.5 ml) is hydrogenated at 40 psi for 30 mins. The mixture is filtered and the catalyst is washed with more water (5 ml). The combined filtrate is extracted with ethyl acetate, concentrated in vacuo to ca. 2 ml, and lyophilized to yield sodium 3-methoxy-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylate.
후처리
- filtrationThe mixture is filtered
- washthe catalyst is washed with more water (5 ml)
- extractionThe combined filtrate is extracted with ethyl acetate
- concentrationconcentrated in vacuo to ca. 2 ml
출처 및 근거
- ORD 기록
- ord-4213cff31b454f0eb5770d8a777320a1
- 출처 데이터셋
- uspto-grants-1983_01
- 특허 번호
- US04369187
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