Water → 2-(4-Fluoro-2-methylphenyl)acetonitrile
반응식
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=1[CH3:10].[C-:11]#[N:12].[K+].O.[I-].[K+]>CC(=O)C>[F:9][C:6]1[CH:7]=[CH:8][C:3]([CH2:2][C:11]#[N:12])=[C:4]([CH3:10])[CH:5]=1참가 물질
6
실험 절차
A mixture of 16 parts of 1-(chloromethyl)-4-fluoro-2-methylbenzene, 7.8 parts of a solution of potassium cyanide in a small amount of water, 0.1 parts of potassium iodide and 240 parts of 2-propanone is stirred and refluxed for 22 hours. The reaction mixture is cooled and filtered. The filtrate is evaported. The residue is taken up in water and the product is extracted with methylbenzene. The extract is dried, filtered and evaporated, yielding 13 parts (87.2%) of 4-fluoro-2-methylbenzeneacetonitrile as a residue.
후처리
- temperaturerefluxed for 22 hours
- temperatureThe reaction mixture is cooled
- filtrationfiltered
- extractionthe product is extracted with methylbenzene
- customThe extract is dried
- filtrationfiltered
- customevaporated
출처 및 근거
- ORD 기록
- ord-a0e0556877194641b9d87def4b3ed5e7
- 출처 데이터셋
- uspto-grants-1983_01
- 특허 번호
- US04369184
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