Water → HCID 53792849, 화합물

HRID 1164368노트

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HRID 1164368 반응식
[Cl:1][C:2]1[C:6]([Cl:7])=[N:5][C:4](=[C:8](Cl)Cl)[N:3]=1.[CH:11]([NH:14][CH:15]=[O:16])([CH3:13])[CH3:12].[OH2:17]>C(#N)C>[CH:15]([N:14]([CH:11]([CH3:13])[CH3:12])[C:8]([C:4]1[NH:5][C:6]([Cl:7])=[C:2]([Cl:1])[N:3]=1)=[O:17])=[O:16]

참가 물질

5

반응물 3

HCID 962WaterHCID 268118N-(propan-2-yl)formamideHCID 124825724,5-Dichloro-2-(dichloromethylidene)-2H-imidazole

생성물 1

HCID 53792849HCID 53792849, 화합물수율 84%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
0 °C

실험 절차

654 g (3 mol) of 4,5-dichloro-2-dichloromethylene-imidazole in a finely powdered form were added incrementally in the course of about one hour, to a mixture, which had been initially introduced, of 783 g (9 mol) of isopropyl-formamide, 162 g (9 mol) of water and 3 l of acetonitrile, while stirring and while cooling to about 0° C. The clear solution was then poured into about 15 kg of ice water. The white precipitate which had formed was filtered off, washed with water and dried. In this way, 630 g (84% of theory) of 4,5-dichloro-imidazole-2-carboxylic acid N-formyl-isopropylamide with a melting point of 142° C. were obtained. The same result was also achieved without the addition of water.

후처리

  1. customThe white precipitate which had formed
  2. filtrationwas filtered off
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-f6fcc053ee0e4ece85666d7f86ef761b
출처 데이터셋
uspto-grants-1983_01
특허 번호
US04369186

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