Nitric Acid → 1,4-Dichloro-2-cyclohexyl-5-nitrobenzene

HRID 1164521

반응식

HRID 1164521 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1.[N+:15]([O-])([OH:17])=[O:16]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:7]=[C:6]([N+:15]([O-:17])=[O:16])[C:5]([Cl:8])=[CH:4][C:3]=1[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 130971441,4-Dichloro-2-cyclohexylbenzene

생성물 1

HCID 130971451,4-Dichloro-2-cyclohexyl-5-nitrobenzene

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매2회

실험 절차

To a solution of 1,4-dichloro-2-cyclohexylbenzene (12.0 g) in conc. sulfuric acid (15 ml) was added dropwise a mixture of nitric acid (d=1.42, 4 ml) and conc.sulfuric acid (6 ml) with stirring under ice-cooling. After the stirring was continued for 10 minutes, ice-water was added to the reaction mixture to give an oily residue, which was extracted with ether, washed with water, dried over magnesium sulfate and concentrated under reduced pressure. The resultant oily residue was distilled under reduced pressure to give 1,4-dichloro-2-cyclohexyl-5-nitrobenzene (10.0 g).

후처리

  1. temperaturecooling
  2. customto give an oily residue, which
  3. extractionwas extracted with ether
  4. washwashed with water
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. distillationThe resultant oily residue was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-1f0da45e7bb24e9f84114a89d982f605
출처 데이터셋
uspto-grants-1983_01
특허 번호
US04370340

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