Dimethyl methoxymalonate → HCID 178442636, 화합물

HRID 1164763

반응식

HRID 1164763 반응식
Cl.[CH2:2]([C:10]1[CH:18]=[CH:17][C:13]([C:14]([NH2:16])=[NH:15])=[CH:12][CH:11]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[CH3:19][O:20][CH:21]([C:26](OC)=[O:27])[C:22](OC)=[O:23]>C(O)(=O)C>[OH:23][C:22]1[C:21]([O:20][CH3:19])=[C:26]([OH:27])[N:16]=[C:14]([C:13]2[CH:12]=[CH:11][C:10]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])=[CH:18][CH:17]=2)[N:15]=1

참가 물질

4

반응물 2

HCID 78718Dimethyl methoxymalonateHCID 136408764-Octylbenzamidine hydrochloride

생성물 1

HCID 178442636HCID 178442636, 화합물수율 89.3%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Metal sodium (23.4 g, 1.02 mol) was added to methanol (500 ml) to obtain sodium methoxide, followed by adding thereto 4-octylbenzamidine hydrochloride (84 g, 0.31 mol) and dimethyl methoxymalonate (55 g, 0.31 mol), refluxing the mixture for 8 hours, pouring the reaction mixture in acetic acid (500 ml), filtering off deposited crystals, washing them with water and drying to obtain 4,6-dihydroxy-5-methoxy-2-(4-octylphenyl)pyrimidine (91.5 g).

후처리

  1. additionby adding
  2. filtrationfiltering off
  3. washwashing them with water
  4. customdrying

출처 및 근거

ORD 기록
ord-02e904e748a5401badc1c433090dffe5
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04906400

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