Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Aluminum(III) Chloride → 6-(3-Carbomethoxy-2-methyl-propionyl)-3,4-dihydro-4-methyl-2(1H)-quinazolinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 반응물 | 4-Methyl-3,4-dihydro-1H-quinazolin-2-one | HCID 12360757 | — |
| 반응물 | Methyl 4-chloro-3-methyl-4-oxobutanoate | HCID 14403282 | — |
| 용매 | Carbon Disulfide | HCID 6348 | — |
| 생성물 | 6-(3-Carbomethoxy-2-methyl-propionyl)-3,4-dihydro-4-methyl-2(1H)-quinazolinone | HCID 14620639 | — |
반응 단계
3,4-Dihydro-4-methyl-2(1H)-quinazolinone (3.9 g) is added to a stirred suspension of anhydrous aluminum chloride (16.5 g) in carbon disulfide (120 ml) under nitrogen. 3-Carbomethoxy-2-methyl-propionyl chloride (4 g) is added dropwise to the stirred suspension, which is refluxed for about 17 hours and cooled to RT. The liquid phase is decanted and the residue is treated with ice/H2O (150 ml) and extracted with methylene chloride. The organic extract is dried, filtered, and concentrated in vacuo, affording the desired crude product as an oil, which is used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04906630 |
| 출처 데이터셋 | uspto-grants-1990_03 |
| ORD ID | ord-2730bdabea554667994afa5299d55c2b |
| 출처 메모 | uspto-grants-1990_03 |