cis 1-Ethoxycarbonyl-2-ethoxycarbonylpyrrolidine-3-ethanol → cis 1-Ethoxycarbonyl-2-ethoxycarbonylpyrrolidine-3-acetaldehyde

HRID 1164894노트

반응식

HRID 1164894 반응식
[CH2:1]([O:3][C:4]([N:6]1[CH2:10][CH2:9][C@H:8]([CH2:11][CH2:12][OH:13])[C@@H:7]1[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:5])[CH3:2].[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[CH2:1]([O:3][C:4]([N:6]1[CH2:10][CH2:9][C@H:8]([CH2:11][CH:12]=[O:13])[C@@H:7]1[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 86743786cis 1-Ethoxycarbonyl-2-ethoxycarbonylpyrrolidine-3-ethanolHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 86743790cis 1-Ethoxycarbonyl-2-ethoxycarbonylpyrrolidine-3-acetaldehyde

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 0.908 g of cis 1-ethoxycarbonyl-2-ethoxycarbonylpyrrolidine-3-ethanol and 1.14 g pyridinium chlorochromate in 20 ml of methylene chloride is stirred under nitrogen for 4 hours. Mixture is filtered and purified by flash chromatography using ethyl acetate/hexane (1:1) to yield cis 1-ethoxycarbonyl-2-ethoxycarbonylpyrrolidine-3-acetaldehyde.

후처리

  1. filtrationMixture is filtered
  2. custompurified by flash chromatography

출처 및 근거

ORD 기록
ord-12a3cf00b53c4ae3aa701ef73a3d8136
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04906621

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