Epichlorohydrin → HCID 19863794, 화합물

HRID 1164932노트

반응식

HRID 1164932 반응식
[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH2:15]([CH:17]1[O:19][CH2:18]1)Cl.[OH-].[K+]>C(O)C.O>[OH:1][CH:2]([C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=1)[O:14][CH2:15][CH:17]1[CH2:18][O:19]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

6

반응물 3

HCID 7835EpichlorohydrinHCID 14797Potassium HydroxideHCID 117900843-(1-Hydroxyhexyl)phenol

생성물 1

HCID 19863794HCID 19863794, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매2회HCID 962Water용매

실험 절차

19.4 g. (0.1 mole) 3-(1-hydroxyhexyl)-phenol and 28.6 g. epichlorohydrin are dissolved in 25 ml. ethanol and heated to the boil. A solution of 6.6 g. potassium hydroxide in 3 ml. water and 25 ml. ethanol is then added dropwise thereto in the course of 15 minutes. The reaction mixture is boiled under reflux for 2 hours, the solvent is then distilled off and the residue is taken up in water. Extraction is carried out with ethyl acetate, the ethyl acetate phase is washed twice with aqueous sodium hydroxide solution and water, dried and evaporated to give 22.4 g. (89% of theory) of the title compound in the form of an oil.

후처리

  1. customin the course of 15 minutes
  2. temperatureunder reflux for 2 hours
  3. distillationthe solvent is then distilled off
  4. extractionExtraction
  5. washthe ethyl acetate phase is washed twice with aqueous sodium hydroxide solution and water
  6. customdried
  7. customevaporated
  8. customto give 22.4 g

출처 및 근거

ORD 기록
ord-c8c56db0a61c438c80c6863e81f2eb53
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04906666

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