Methanol → Methyl 3-(2-hydroxyphenyl)prop-2-enoate

HRID 1164998

반응식

HRID 1164998 반응식
[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=[O:7].[CH3:13]O>S(=O)(=O)(O)O>[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([O:8][CH3:13])=[O:7]

참가 물질

4

반응물 2

HCID 887MethanolHCID 119683-(2-Hydroxyphenyl)-2-propenoic acid

생성물 1

HCID 89400Methyl 3-(2-hydroxyphenyl)prop-2-enoate수율 92%

시약·촉매·용매 1

HCID 1118Sulfuric Acid촉매

실험 절차

A solution of 200 g (1.218 mole) of 2-hydroxycinnamic acid in 2L of anhydrous methanol was treated with 10 drops of concentrated sulfuric acid. This solution was refluxed for 72 hr., using a Soxhlet extractor charged with 200 g of 3A molecular sieves. The methanolic solution was then concentrated under reduced pressure and cooled to afford 200 g (92%) of white crystals, which were used directly in the next step without additional purification.

후처리

  1. temperatureThis solution was refluxed for 72 hr
  2. concentrationThe methanolic solution was then concentrated under reduced pressure
  3. temperaturecooled

출처 및 근거

ORD 기록
ord-be57951fd8e942fcb9f559f8ba454413
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04906661

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