Methyl 2-cyanonicotinate → HCID 19862615, 화합물

HRID 1165164노트

반응식

HRID 1165164 반응식
C[O-].[Na+].[C:4]([C:6]1[N:15]=[CH:14][CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9])#[N:5].[Cl:16][C:17]1[CH:18]=[C:19]([C:23]2[S:24][CH:25]=[C:26](CO)[N:27]=2)[CH:20]=[CH:21][CH:22]=1>C1(C)C=CC=CC=1>[C:4]([C:6]1[N:15]=[CH:14][CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH2:11][C:26]1[N:27]=[C:23]([C:19]2[CH:20]=[CH:21][CH:22]=[C:17]([Cl:16])[CH:18]=2)[S:24][CH:25]=1)=[O:9])#[N:5]

참가 물질

5

반응물 3

HCID 339115Methyl 2-cyanonicotinateHCID 10942334Sodium MethoxideHCID 14330272(2-(3-Chlorophenyl)thiazol-4-yl)methanol

생성물 1

HCID 19862615HCID 19862615, 화합물수율 25.3%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Sodium methylate (0.11 g; 0.002 mole) is added to a solution of methyl 2-cyanonicotinate (3.24 g; 0.02 mole) and 2-(3-chlorophenyl)-4-(hydroxymethyl)thiazole (4.96 g; 0.022 mole) in toluene (100 cc). The methanol/toluene azeotrope is distilled off and the toluene is then evaporated off. The residue is treated with water. The precipitate formed is filtered off, washed with water and then dried. Compound 2 (1.8 g; 25% m.p. 130° C.) is obtained.

후처리

  1. distillationThe methanol/toluene azeotrope is distilled off
  2. customthe toluene is then evaporated off
  3. additionThe residue is treated with water
  4. customThe precipitate formed
  5. filtrationis filtered off
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-77eb3f77bea946e49e5d3dd9a4f13441
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04908375

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