(S)-2-amino-1,1-di-(2'-methoxyphenyl)-4-methylpentan-1-ol acetate → Uniconazole

HRID 1165371

반응식

HRID 1165371 반응식
[ClH:1].[NH2:2][C@@H:3](C)C(C1C=CC=CC=1)(C1C=CC=CC=1)O.Cl.[NH2:20][C@@H:21](C(C)C)C(C1C=CC=CC=1)(C1C=CC=CC=1)O.C([O:42][C:43]([C:59]1[CH:64]=CC=C[CH:60]=1)(C1C=CC=CC=1)[C@H:44]([NH2:52])[CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)(=O)C.[C:65](OC(C1C=CC=CC=1OC)(C1C=CC=CC=1OC)[C@@H](N)CC(C)C)(=O)C>>[Cl:1][C:49]1[CH:48]=[CH:47][C:46](/[CH:45]=[C:44](/[N:52]2[CH:3]=[N:2][CH:21]=[N:20]2)\[CH:43]([OH:42])[C:59]([CH3:60])([CH3:64])[CH3:65])=[CH:51][CH:50]=1

참가 물질

5

반응물 4

HCID 18638008(S)-2-amino-1,1-di-(2'-methoxyphenyl)-4-methylpentan-1-ol acetateHCID 18638009(S)-2-Amino-3-methyl-1,1-diphenylbutan-1-ol hydrochlorideHCID 54165093(R)-2-amino-1,1-diphenyl-3-phenylpropan-1-ol acetateHCID 67707196(S)-2-Amino-1,1-diphenylpropan-1-ol hydrochloride

생성물 1

HCID 6436604Uniconazole

실험 절차

Reaction was carried out according to Example 1 using (S)-2-amino-1,1-diphenylpropan-1-ol hydrochloride, (S)-2-amino-1,1-diphenyl-3-methylbutan-1-ol hydrochloride, (R)-2-amino-1,1-diphenyl-3-phenylpropan-1-ol acetate and (S)-2-amino-1,1-di-(2'-methoxyphenyl)-4-methylpentan-1-ol acetate in place of (S)-2-amino-1,1-diphenyl-4-methylpentan-1-ol hydrochloride, to obtain the (+)-isomer and (-)-isomer of (E)-1-(4-chlorophenyl)-2-(1,2,4-triazol-1-yl)-4,4- dimethyl-1-penten-3-ol. The results obtained were summarized in Table 1.

후처리

  1. customReaction

출처 및 근거

ORD 기록
ord-e03e884e406b46c9959a03ae6d956ea1
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04908455

연결된 노트

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