1-Bromo-3-chloro-2,4-difluoro-5-nitrobenzene → 5-Bromo-3-chloro-2,4-difluoroaniline

HRID 1165409노트

반응식

HRID 1165409 반응식
[F:1][C:2]1[C:7]([Cl:8])=[C:6]([F:9])[C:5]([Br:10])=[CH:4][C:3]=1[N+:11]([O-])=O>O1CCCC1.[Re]>[F:1][C:2]1[C:7]([Cl:8])=[C:6]([F:9])[C:5]([Br:10])=[CH:4][C:3]=1[NH2:11]

참가 물질

4

반응물 1

HCID 198616351-Bromo-3-chloro-2,4-difluoro-5-nitrobenzene

생성물 1

HCID 198616345-Bromo-3-chloro-2,4-difluoroaniline

시약·촉매·용매 2

HCID 23947Rhenium촉매HCID 8028Tetrahydrofuran용매

실험 절차

7.6 g of 2,4-difluoro-3-chloro-5-bromonitrobenzene are dissolved in 80 ml of tetrahydrofuran and hydrogenated at from +20° to 25° C. over a period of 4 hours in the presence of 1.7 g of 5% rhenium-on-carbon (hydrogen absorbed: 1.88 l). The reaction mixture is filtered, the solvent is removed by distillation, and the residue is suspended in hexane and filtered off with suction. The title compound of formula ##STR12## is obtained in the form of colourless crystals; m.p. 86°-88° C.

후처리

  1. filtrationThe reaction mixture is filtered
  2. customthe solvent is removed by distillation
  3. filtrationfiltered off with suction

출처 및 근거

ORD 기록
ord-a24bcc5dcf1a4a518db0ebb7c5298105
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04910018

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