Potassium Hydroxide → 4-chloro-2-(4-chlorophenyl)-5-(4-trifluoromethylbenzyloxy)-3(2H)-pyridazinone

HRID 1165428

반응식

HRID 1165428 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[C:12]([Cl:15])=[C:11](Cl)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[F:17][C:18]([F:28])([F:27])[C:19]1[CH:26]=[CH:25][C:22]([CH2:23][OH:24])=[CH:21][CH:20]=1.[OH-].[K+]>CN(C)C=O>[Cl:15][C:12]1[C:13](=[O:14])[N:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:9]=[CH:10][C:11]=1[O:24][CH2:23][C:22]1[CH:21]=[CH:20][C:19]([C:18]([F:17])([F:27])[F:28])=[CH:26][CH:25]=1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 676844-(Trifluoromethyl)benzenemethanolHCID 7794024,5-Dichloro-2-(4-chlorophenyl)-3(2H)-pyridazinone

생성물 1

HCID 140722484-chloro-2-(4-chlorophenyl)-5-(4-trifluoromethylbenzyloxy)-3(2H)-pyridazinone수율 59.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In 30 ml of N,N-dimethylformamide were dissolved 1.0 g (3.6 m mol) of 2-(4-chlorophenyl)-4,5-dichloro-3(2H)-pyridazinone and 0.64 g (3.6 m mol) of p-trifluoromethylbenzyl alcohol, and thereto was added 0.24 g of powdery potassium hydroxide. The reaction mixture was stirred at room temperature for one day. Then, the procedures in Synthesis Example 2 were repeated to give 900 mg of the intended compound.

후처리

  1. customThen, the procedures in Synthesis Example 2

출처 및 근거

ORD 기록
ord-eeea809c9afa424a8edd70df7048a03e
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04910201

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