Hexane → 1H-Indole-4-carbonyl chloride

HRID 1165455노트

반응식

HRID 1165455 반응식
[NH:1]1[C:9]2[C:4](=[C:5]([C:10]([OH:12])=O)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.C(Cl)(=O)C([Cl:16])=O.CCCCCC>C(Cl)Cl>[NH:1]1[C:9]2[C:4](=[C:5]([C:10]([Cl:16])=[O:12])[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

참가 물질

5

반응물 3

HCID 8058HexaneHCID 65578Oxalyl chlorideHCID 595229Indole-4-carboxylic acid

생성물 1

HCID 144031811H-Indole-4-carbonyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
20 °C

실험 절차

32.2 g (0.2M) dry indol-4-yl carboxylic acid are suspended in 150 ml absolute methylene chloride. 26 ml (0.3M) oxalyl chloride are added to the stirred mixture at 20° over 30 minutes. Gas evolution results. The mixture is stirred for 31/2 hours at 20° C. 150 ml Hexane are added. The mixture is stirred for another 20 minutes and the resultant heading compound filtered off, washed with methylene chloride/hexane 1:1 dried at 20° in a vacuum to give beige crystals, which are used further without purification.

후처리

  1. customGas evolution results
  2. stirringThe mixture is stirred for another 20 minutes
  3. filtrationfiltered off
  4. washwashed with methylene chloride/hexane 1:1
  5. customdried at 20° in a vacuum
  6. customto give beige crystals, which
  7. customare used further without purification

출처 및 근거

ORD 기록
ord-73741de9c6704e08926de72d3c5ae61b
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04910207

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