Methoxyacetyl chloride → 3,5-Bis(methoxyacetylamino)-4-chlorobenzonitrile

HRID 1165880노트

반응식

HRID 1165880 반응식
[Cl:1][C:2]1[C:9]([NH2:10])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[NH2:11].[CH3:12][O:13][CH2:14][C:15](Cl)=[O:16]>N1C=CC=CC=1>[CH3:12][O:13][CH2:14][C:15]([NH:11][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([NH:10][C:15](=[O:16])[CH2:14][O:13][CH3:12])[C:2]=1[Cl:1])[C:6]#[N:7])=[O:16]

참가 물질

4

반응물 2

HCID 96623Methoxyacetyl chlorideHCID 124029953,5-Diamino-4-chlorobenzonitrile

생성물 1

HCID 146992833,5-Bis(methoxyacetylamino)-4-chlorobenzonitrile

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 4-chloro-3,5-diaminobenzonitrile (3.34 g) in pyridine (60 ml) is added dropwise methoxyacetyl chloride (4.0 ml) at room temperature. The mixture is stirred at room temperature for 2 hours, and thereafter, pyridine is distilled off under reduced pressure. To the residue is added water, and the resulting solid substance is separated by filtration and washed with water. The resulting crude crystals are recrystallized from ethanol to give the title compound (5.1 g) having the following physical properties.

후처리

  1. distillationpyridine is distilled off under reduced pressure
  2. additionTo the residue is added water
  3. customthe resulting solid substance is separated by filtration
  4. washwashed with water
  5. customThe resulting crude crystals are recrystallized from ethanol

출처 및 근거

ORD 기록
ord-012e51196b8f4431b52d32b3bb8cf243
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04912135

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