홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

2-Chloropyrimidine → 2-Pyrimidinamine, N-(1-(1-((4-fluorophenyl)methyl)-1H-benzimidazol-2-yl)-4-piperidinyl)-

HRID 1165921
노트
인쇄 미리보기

반응식

HRID 1165921 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[N:11]=[C:10]2[N:18]2[CH2:23][CH2:22][CH:21]([NH2:24])[CH2:20][CH2:19]2)=[CH:4][CH:3]=1.Cl[C:26]1[N:31]=[CH:30][CH:29]=[CH:28][N:27]=1.C(=O)(O)[O-].[Na+]>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[N:11]=[C:10]2[N:18]2[CH2:23][CH2:22][CH:21]([NH:24][C:26]3[N:31]=[CH:30][CH:29]=[CH:28][N:27]=3)[CH2:20][CH2:19]2)=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 744042-ChloropyrimidineHCID 516892Sodium BicarbonateHCID 110127714-Piperidinamine, 1-[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]-

생성물 1

HCID 30657042-Pyrimidinamine, N-(1-(1-((4-fluorophenyl)methyl)-1H-benzimidazol-2-yl)-4-piperidinyl)-

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 1.71 g (0.005 mole) of 1-{1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl}-4-piperidinamine, 0.57 g (0.005 mole) of 2-chloropyrimidine, 0.43 g (0.052 mole) of sodium bicarbonate and 19 ml of ethanol is brought to reflux temperature for 2 days and 2 nights. The mixture is evaporated to dryness, and water and 2N sodium hydroxide are added. The product is taken up with methylene chloride, decanted and washed with water. The product is chromatographed on a silica column (eluent: dichloromethane/methanol, 47:3).

후처리

  1. temperatureto reflux temperature for 2 days
  2. custom2 nights
  3. customThe mixture is evaporated to dryness, and water and 2N sodium hydroxide
  4. additionare added
  5. customdecanted
  6. washwashed with water
  7. customThe product is chromatographed on a silica column (eluent: dichloromethane/methanol, 47:3)

출처 및 근거

ORD 기록
ord-c56f10dac4c140179138516cfa7558c6
출처 데이터셋
uspto-grants-1990_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04912219

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트