Water → 1-(2-Chloro-5-nitrophenyl)-2-(2,2-dimethylpropionyl)hydrazine

HRID 1165928노트

반응식

HRID 1165928 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11][NH2:12].C(N(CC)CC)C.[C:20](Cl)(=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22].O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[NH:11][NH:12][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 62493Pivaloyl chlorideHCID 4103137(2-Chloro-5-nitrophenyl)hydrazine

생성물 1

HCID 142806541-(2-Chloro-5-nitrophenyl)-2-(2,2-dimethylpropionyl)hydrazine수율 77.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-chloro-5-nitrophenylhydrazine (37.60 g) in dichloromethane (200 ml), triethylamine (22.27 g) and pivaloyl chloride (26.59 g) were added, and the resultant mixture was stirred at room temperature for 12 hours. The reaction mixture was combined with water. The dichloromethane layer was washed with water, dried and concentrated under reduced pressure to give 1-(2-chloro-5-nitrophenyl)-2-(2,2-dimethylpropionyl)hydrazine (42.23 g). m.p., 153.3° C..

후처리

  1. washThe dichloromethane layer was washed with water
  2. customdried
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8b0224c2604e45d4a79598f762f80c84
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04912225

반응 노트

불러오는 중…