Sulfuric Acid → HCID 178491962, 화합물

HRID 1165933노트

반응식

HRID 1165933 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]([NH:12][CH2:13][CH:14](OC)OC)=[S:11])=[CH:5][CH:4]=1.S(=O)(=O)(O)O>O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:14]=[CH:13][N:12]=[C:10]2[SH:11])=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 8820791-(2,2-Dimethoxyethyl)-3-(4-methoxyphenyl)thiourea

생성물 1

HCID 178491962HCID 178491962, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 10 g (0.06 mole) of p-methoxyphenyl isothiocyanate in 100 ml of chloroform was treated with 6.3 g (0.06 mole) of aminoacetaldehyde dimethyl acetal. The solvent was evaporated and the residue was recrystallized from ethanol to yield N-(p-methoxyphenyl)-N'-(β,β-dimethoxyethyl)thiourea, 9.2 g (57%). A suspension of this thiourea in a solution of 5 ml of concentrated sulfuric acid and 20 ml of water was refluxed for 3 hours. The mixture was cooled and a solid was filtered, washed with water, and dried. Recrystallization from ethanol gave 1-(4-methoxyphenyl)-2-mercaptoimidazole, 4.9 g (70%), mp 215°-217° C.

후처리

  1. temperaturewas refluxed for 3 hours
  2. temperatureThe mixture was cooled
  3. filtrationa solid was filtered
  4. washwashed with water
  5. customdried
  6. customRecrystallization from ethanol

출처 및 근거

ORD 기록
ord-e56ebb6382e74320a6a2adea2e0f95e4
출처 데이터셋
uspto-grants-1990_03
특허 번호
US04912226

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