Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenyltrimethylsilane → trans-1-Benzoyl-4-phenyl-l-proline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenyltrimethylsilane | HCID 69849 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 반응물 | cis-1-benzoyl-4-((4-methylsulfonyl)oxy)-L-proline | HCID 11120569 | — |
| 용매 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 생성물 | trans-1-Benzoyl-4-phenyl-l-proline | HCID 46864073 | — |
반응 단계
A suspension of powdered (cis)-1-benzoyl-4-mesyloxy-L-proline (250 mg, 0.8 mmole) in 1,2-dichlorobenzene (3 ml) was stirred under argon and treated with phenyltrimethylsilane (1 ml, 5.8 mmole) followed by aluminum trichloride (383 mg, 2.87 mmole). The reaction was stirred overnight and an aliquot was removed, quenched into 1N HCl and extracted with ethyl acetate. Analysis of the organic layer by tlc showed the presence of:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04912231 |
| 출처 데이터셋 | uspto-grants-1990_03 |
| ORD ID | ord-8c8b1083c13a4d1e80804b6e0001a43a |
| 출처 메모 | uspto-grants-1990_03 |