1-Benzylpiperazine → 2-(4-Chlorophenyl)-4-(4-benzylpiperazino)-6,7,8-trimethoxyquinazoline

HRID 1166151노트

반응식

HRID 1166151 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16](Cl)[C:15]3[C:10](=[C:11]([O:23][CH3:24])[C:12]([O:21][CH3:22])=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.[CH2:25]([N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:17]=[C:16]([N:35]3[CH2:36][CH2:37][N:32]([CH2:25][C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)[CH2:33][CH2:34]3)[C:15]3[C:10](=[C:11]([O:23][CH3:24])[C:12]([O:21][CH3:22])=[C:13]([O:19][CH3:20])[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 759941-BenzylpiperazineHCID 117834712-(4-Chlorophenyl)-4-chloro-6,7,8-trimethoxyquinazoline

생성물 1

HCID 111239992-(4-Chlorophenyl)-4-(4-benzylpiperazino)-6,7,8-trimethoxyquinazoline

반응 조건

온도
150 °C

실험 절차

A mixture of 2.0 g of 2-(4-chlorophenyl)-4-chloro-6,7,8-trimethoxyquinazoline and 5.0 g of N-benzylpiperazine was heated at 150° C. for 1 h. After cooling, 20 ml of ice water were added and the mixture was extracted with ethyl acetate. The organic phase was dried over sodium sulfate and concentrated. The oily crude product thus obtained was recrystallized from isopropanol. Yield: 1 g. M.p.: 150° C.

후처리

  1. temperatureAfter cooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6747592a7e76453cb68696400a8b36fa
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06613772B1

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