Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → (S)-3-Cyclohexylbutyroyl Chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | (3S)-3-phenylbutanoic acid | HCID 852991 | — |
| 촉매 | Rhodium | HCID 23948 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | (S)-3-Cyclohexylbutyroyl Chloride | HCID 12085190 | — |
반응 단계
(S)-3-phenylbutyric acid was hydrogenated using Rh/C in MeOH at 60 psi and 60° C. for 3.2 hours. The reduced product was then converted to the title acid chloride by treating with 1 eq of oxalyl chloride, and a catalytic amount of DMF, in toluene for 90 minutes, followed by evaporation of the volatile materials.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06613880B2 |
| 출처 데이터셋 | uspto-grants-2003_09 |
| ORD ID | ord-e425d4f156254adc9d08a4f60024b1b6 |
| 출처 메모 | uspto-grants-2003_09 |