n1-Isopropoxy-3-nitro-1-benzenesulfonamide → 3-Amino-n1-isopropoxy-1-benzenesulfonamide

HRID 1166460노트

반응식

HRID 1166460 반응식
[CH:1]([O:4][NH:5][S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-])=O)[CH:10]=1)(=[O:8])=[O:7])([CH3:3])[CH3:2]>[Pd].[O-]S([O-])(=O)=O.[Ba+2]>[NH2:15][C:11]1[CH:10]=[C:9]([S:6]([NH:5][O:4][CH:1]([CH3:3])[CH3:2])(=[O:7])=[O:8])[CH:14]=[CH:13][CH:12]=1

참가 물질

3

반응물 1

HCID 22997071n1-Isopropoxy-3-nitro-1-benzenesulfonamide

생성물 1

HCID 229971243-Amino-n1-isopropoxy-1-benzenesulfonamide수율 96%

시약·촉매·용매 1

HCID 16218511Pd barium sulfate촉매

실험 절차

To a Parr H2 vessel containing 5% Pd/BaSO4 (0.350g) was added a methanolic solution (125 mL) of N1-isopropoxy-3-nitro-1-benzenesulfonamide (3.50 g, 0.0135 mol) at rt under Ar atm. The solution was hydrogenated at 45psi for approx. 1.0 h. The reaction mixtire was filtered (1/2″ celite pad) and evaporated to give the product as yellow crystalline solid 2.90 g (96%). 1H NMR (CDCl3) 1.20(d,25H); 4.27(m,1H) 7.05(s,1H); 7.75(1,1H); 8.22(d,1H); 8.48 (dd,1H); 8.74(t, 1H).

후처리

  1. filtrationThe reaction mixtire was filtered (1/2″ celite pad) and
  2. customevaporated

출처 및 근거

ORD 기록
ord-ad02443a45924cc6b3c20b7a2512a0c3
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06613743B2

반응 노트

불러오는 중…