Nitric Acid → 4-Methyl-1-nitronaphthalene

HRID 1166787

반응식

HRID 1166787 반응식
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.OS(O)(=O)=O.[N+:17]([O-])([OH:19])=[O:18]>C(OCC)(=O)C>[N+:17]([C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([CH3:1])=[CH:3][CH:4]=1)([O-:19])=[O:18]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 70021-Methylnaphthalene

생성물 1

HCID 701554-Methyl-1-nitronaphthalene

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a cold (0° C.) suspension of 1-methylnaphthalene (5 g) in HNO3 was added H2SO4 (5 mL) dropwise. After stirring the reaction for one hour, the solution was diluted with ethyl acetate and washed with water (3×), aqueous saturated NaHCO3 (2×) and brine, dried over MgSO4, and concentrated. The product was purified by silica gel column chromatography using ethyl acetate:hexane (5:95) and recrystallized from methanol to give yellow needles.

후처리

  1. customthe reaction for one hour
  2. washwashed with water (3×), aqueous saturated NaHCO3 (2×) and brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated
  5. customThe product was purified by silica gel column chromatography
  6. customrecrystallized from methanol
  7. customto give yellow needles

출처 및 근거

ORD 기록
ord-c0acf37e673345a29bf4550df46cc2ac
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06613942B1

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