Isopropyl iodide → 2-(Propan-2-yl)-1-benzothiophene
반응식
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2.[Li][C:11](C)([CH3:13])[CH3:12].IC(C)C>C1COCC1>[CH:11]([C:5]1[S:1][C:2]2[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=2[CH:4]=1)([CH3:13])[CH3:12]참가 물질
5
실험 절차
2-i-Propylbenzo[b]thiophene was prepared by the method of Example 40A with benzo[b]thiophene (7.5 mmoles, 1.0 g), t-BuLi (1.7 M, 11.2 mmoles, 6.6 ml), 2-iodopropane (11.2 mmoles, 1.12 ml) and THF (20 ml) with stirring at ambient temperature for 24 hrs. It was isolated as a yellow oil (1.11 g; 85% yield).
후처리
- customIt was isolated as a yellow oil (1.11 g; 85% yield)
출처 및 근거
- ORD 기록
- ord-37baf78d3fbe49f49690b591066b0cc4
- 출처 데이터셋
- uspto-grants-2003_09
- 특허 번호
- US06613804B2
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