4-Bromo-3-methylisoxazol-5-amine → HCID 23445238, 화합물

HRID 1166887노트

반응식

HRID 1166887 반응식
Cl[S:2]([C:5]1[S:9][C:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[NH2:18][C:19]1[O:23][N:22]=[C:21]([CH3:24])[C:20]=1[Br:25]>>[Br:25][C:20]1[C:21]([CH3:24])=[N:22][O:23][C:19]=1[NH:18][S:2]([C:5]1[S:9][C:8]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3]

참가 물질

3

반응물 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 22998474HCID 22998474, 화합물

생성물 1

HCID 23445238HCID 23445238, 화합물

실험 절차

N-(4-bromo-3-methyl-5-isoxazolyl)-5-(4-methoxyphenyl)thiophene-2-sulfonamide was prepared in the same manner as described in Example 1. Reaction of 5-chlorosulfonyl-2-(4-methoxyphenyl)thiophene with 5-amino-4-bromo-3-methylisoxazole gave N-(4-bromo-3-methyl-5-isoxazolyl)-5-(4-methoxyphenyl)thiophene-2-sulfonamide in 50% yield, m.p. 128-130° C.

후처리

  1. customN-(4-bromo-3-methyl-5-isoxazolyl)-5-(4-methoxyphenyl)thiophene-2-sulfonamide was prepared in the same manner

출처 및 근거

ORD 기록
ord-7f683ee0f41a4845a2e47b0ab30666a1
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06613804B2

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