Dimethylformamide → 2-(4-Methoxybenzyl)-benzo[b]thiophene-3-sulfonylchloride

HRID 1166910

반응식

CN(C=O)C.[S:6]([Cl:10])(Cl)(=[O:8])=[O:7].[CH3:11][O:12][C:13]1[CH:28]=[CH:27][C:16]([CH2:17][C:18]2[S:22][C:21]3[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=3[CH:19]=2)=[CH:15][CH:14]=1>>[CH3:11][O:12][C:13]1[CH:14]=[CH:15][C:16]([CH2:17][C:18]2[S:22][C:21]3[CH:23]=[CH:24][CH:25]=[CH:26][C:20]=3[C:19]=2[S:6]([Cl:10])(=[O:8])=[O:7])=[CH:27][CH:28]=1

참가 물질

반응물 3

HCID 6228Dimethylformamide

HCID 24648Sulfuryl chloride

HCID 22998384HCID 22998384, 화합물

생성물 1

HCID 229985102-(4-Methoxybenzyl)-benzo[b]thiophene-3-sulfonylchloride

실험 절차

2-(4-methoxybenzyl)-benzo[b]thiophene-3-sulfonylchloride was prepared by the method of Example 40B with DMF (3.2 mmoles, 0.24 ml), sulfurylchloride (2.7 mmoles, 0.22 ml) and 2-(4-methoxybenzyl)-benzo[b]thiophene (1.6 mmoles. 0.4 g). Flash chromatography using 2% ethyl acetate/hexanes provided 0.19 g (33%) of a light yellow solid.

출처 및 근거

ORD 기록: ord-1484315ede1b418483ea761c7be39fe0
출처 데이터셋: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06613804B2

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