2-Formylphenylboronic acid → N-(3-methyl-5-isoxazolyl)-5-(2-formylphenyl)thiophene-2-sulfonamide

HRID 1166964

반응식

HRID 1166964 반응식
[CH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1B(O)O)=[O:2].[CH3:12][C:13]1[CH:17]=[C:16]([NH:18][S:19]([C:22]2[S:23][C:24](Br)=[CH:25][CH:26]=2)(=[O:21])=[O:20])[O:15][N:14]=1>>[CH3:12][C:13]1[CH:17]=[C:16]([NH:18][S:19]([C:22]2[S:23][C:24]([C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[CH:1]=[O:2])=[CH:25][CH:26]=2)(=[O:21])=[O:20])[O:15][N:14]=1

참가 물질

3

반응물 2

HCID 2921892-Formylphenylboronic acidHCID 22998516N-(3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide

생성물 1

HCID 22998472N-(3-methyl-5-isoxazolyl)-5-(2-formylphenyl)thiophene-2-sulfonamide수율 28%

실험 절차

N-(3-methyl-5-isoxazolyl)-5-(2-formylphenyl)thiophene-2-sulfonamide was prepared in the same manner as described in Example 32C from 2-formylbenzeneboronic acid (281 mg, 1.87 mmol) and N-(3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide (550 mg, 1.7 mmol). Purification by column chromatography using 15% MeOH/CHCl3 gave 163 mg (28%) of the pure sulfonamide as a brown oil.

후처리

  1. customN-(3-methyl-5-isoxazolyl)-5-(2-formylphenyl)thiophene-2-sulfonamide was prepared in the same manner
  2. customPurification by column chromatography

출처 및 근거

ORD 기록
ord-acf891c03ea44682b0cf2c05764ca189
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06613804B2

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