Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1167107생성일: 2026년 10월 27일
Triethylamine → Methyl 2-methyl-2-phenyl-5-{4-[(biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate
https://huagongshe.com/reaction/1167107
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-[(2-Biphenyl)carbonylamino]piperidine | HCID 11391851 | — |
| 반응물 | Methyl 5-bromo-2-methyl-2-phenyl-pentanecarboxylate | HCID 22995606 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl 2-methyl-2-phenyl-5-{4-[(biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate | HCID 22995520 | — |
반응 단계
A solution of 0.634 g (0.002 mol) of biphenyl-2-carboxylic acid-piperidin-4-ylamide, 0.5 g (1.75 mmol) of methyl 5-bromo-2-methyl-2-phenyl-pentanecarboxylate and 1 ml (0.007 mol) of triethylamine are dissolved in 3 ml dimethylformamide. The mixture is stirred for 14 hours at 80° C. Then the reaction mixture is poured onto water and extracted with ethyl acetate. The organic phase is dried over sodium sulphate. After column chromatography on silica gel (eluant: dichloromethane/methanol=10:1) colourless crystals remain.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06617325B1 |
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| 출처 데이터셋 | uspto-grants-2003_09 |
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| ORD ID | ord-be0aaedc435e4e1c9fd25e02e5d8de5a |
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| 출처 메모 | uspto-grants-2003_09 |
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