Chlorosulfonic acid → 2,5-Dichloro-4-methylbenzene-1-sulfonyl chloride
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[CH3:9].[Cl:10][S:11](O)(=[O:13])=[O:12]>>[Cl:8][C:5]1[CH:4]=[C:3]([CH3:9])[C:2]([Cl:1])=[CH:7][C:6]=1[S:11]([Cl:10])(=[O:13])=[O:12]참가 물질
3
반응 조건
- 온도
- 0 °C
실험 절차
A dry flask under argon was charged with chlorosulfonic acid (30 mL) and cooled to 0° C. 2,5-Dichlorotoluene (10 g, 62.1 mmol) was then added dropwise, and once the addition was complete, the reaction was heated to 60° C. and stirred for 30 min. After cooling to room temperature, the reaction mixture was poured slowly onto ice. The aqueous mixture was extracted twice with methylene chloride, and the organics were dried and concentrated to provide 2,5-dichloro-4-methylbenzenesulfonyl chloride (14.14 g, 88%) as a white solid.
후처리
- additiononce the addition
- temperaturethe reaction was heated to 60° C.
- temperatureAfter cooling to room temperature
- additionthe reaction mixture was poured slowly onto ice
- extractionThe aqueous mixture was extracted twice with methylene chloride
- customthe organics were dried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-4aa8bc8e7f39416b9f73f8c00afc4573
- 출처 데이터셋
- uspto-grants-2003_09
- 특허 번호
- US06617357B2
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