3-Fluoro-4-(3-cyano-1-pyrrolyl)nitrobenzene → 5-Amino-2-(3-cyano-1-pyrrolyl)fluorobenzene

HRID 1167465노트

반응식

HRID 1167465 반응식
[F:1][C:2]1[CH:3]=[C:4]([N+:15]([O-])=O)[CH:5]=[CH:6][C:7]=1[N:8]1[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[CH:9]1>CO.[Pd]>[NH2:15][C:4]1[CH:5]=[CH:6][C:7]([N:8]2[CH:12]=[CH:11][C:10]([C:13]#[N:14])=[CH:9]2)=[C:2]([F:1])[CH:3]=1

참가 물질

4

반응물 1

HCID 229960033-Fluoro-4-(3-cyano-1-pyrrolyl)nitrobenzene

생성물 1

HCID 229961405-Amino-2-(3-cyano-1-pyrrolyl)fluorobenzene

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

3-Fluoro-4-(3-cyano-1-pyrrolyl)nitrobenzene (5.3 g, 22.9 mmnol) was dissolved in hot MeOH (250 ml) and palladium catalyst (10% on charcoal, 700 mg) added under a nitrogen atmosphere. The mixture was cooled and hydrogenated at atmospheric pressure for 3.5 hours. After filtration through celite, the solution was evaporated to dryness to give title product in sufficent purity for the next stage (4.6 g).

후처리

  1. temperatureThe mixture was cooled
  2. filtrationAfter filtration through celite
  3. customthe solution was evaporated to dryness

출처 및 근거

ORD 기록
ord-312b9797beda4aba96ca2a5a0f066241
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06617339B1

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