HCID 497421, 화합물 → HCID 69983189, 화합물

HRID 1167468

반응식

HRID 1167468 반응식
O[CH:2]1[CH2:5][N:4]([C:6]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:16][C@H:15]([CH2:17][O:18][C:19]4[CH:23]=[CH:22][O:21][N:20]=4)[O:14][C:13]3=[O:24])=[CH:8][C:7]=2[F:25])[CH2:3]1.FC1C=C(N2C[C@H](CO)OC2=O)C=C[C:32]=1[N:33]1C=CN=C1C>>[F:25][C:7]1[CH:8]=[C:9]([N:12]2[CH2:16][C@H:15]([CH2:17][O:18][C:19]3[CH:23]=[CH:22][O:21][N:20]=3)[O:14][C:13]2=[O:24])[CH:10]=[CH:11][C:6]=1[N:4]1[CH:3]=[CH:32][N:33]=[C:5]1[CH3:2]

참가 물질

3

반응물 2

HCID 497421HCID 497421, 화합물HCID 21356557(5R)-3-(3-Fluoro-4-(2-methylimidazol-1-yl)phenyl)-5-hydroxymethyloxazolidin-2-one

생성물 1

HCID 69983189HCID 69983189, 화합물

실험 절차

Using essentially the same procedure as for the intermediate of Example 65, but starting with 3-(3-fluoro-4-(2-methyl-imidazol-1-yl)phenyl)-5(R)-hydroxymethyloxazolidin-2-one (202 mg, 0.69 mmol), and purifying by chromatography on a 10 g silica Mega Bond Elut® column, eluting with a gradient increasing in polarity from 0 to 2.5% MeOH in dichloromethane, the title compound was prepared (137 mg).

후처리

  1. custompurifying by chromatography on a 10 g silica Mega Bond Elut® column
  2. washeluting with a gradient
  3. temperatureincreasing in polarity from 0 to 2.5% MeOH in dichloromethane

출처 및 근거

ORD 기록
ord-ad97199a624f4a19942add03c6b27245
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06617339B1

연결된 노트

불러오는 중…