4-Methoxy-2-(methoxymethoxy)aniline → HCID 178446839, 화합물

HRID 1167635노트

반응식

HRID 1167635 반응식
[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:6]=1[NH2:7]>ClCCl>[CH3:1][O:2][CH2:3][O:4][C:5]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:6]=1[NH:7][C:6](=[NH:7])[CH2:5][CH2:11][CH2:10][CH3:9]

참가 물질

3

반응물 1

HCID 543397254-Methoxy-2-(methoxymethoxy)aniline

생성물 1

HCID 178446839HCID 178446839, 화합물수율 159.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 1-methoxypentaimidate (11.3 g, 0.109 mol) in dichloromethane (20 ml) was added freshly prepared 2-methoxymethoxy-4-methoxy aniline (10.0 g, 0.055 mol) of Example 1(d) and the mixture was stirred at reflux for 3 days. After removing the solvent flash chromatography of the residue (silica gel, 5% methanol/dichloromethane) afforded the title compound as a dark solid (11.7 g, 85%).

후처리

  1. temperatureat reflux for 3 days
  2. customAfter removing the solvent flash chromatography of the residue (silica gel, 5% methanol/dichloromethane)

출처 및 근거

ORD 기록
ord-a423f58284f24465993f9e0d47c4f6c8
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06620826B2

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