p-Toluenesulfonic acid → 1,2-Difluoro-4-(prop-1-en-2-yl)benzene

HRID 1167706노트

반응식

HRID 1167706 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:9](O)([CH3:11])[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1C=CC=CC=1>[F:8][C:7]1[CH:6]=[CH:5][C:4]([C:9]([CH3:11])=[CH2:10])=[CH:3][C:2]=1[F:1]

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 108210712-(3,4-Difluorophenyl)propan-2-ol

생성물 1

HCID 155252121,2-Difluoro-4-(prop-1-en-2-yl)benzene

시약·촉매·용매 1

HCID 241Benzene용매

반응 조건

온도
60 °C

실험 절차

To a solution of 2-(3,4-difluorophenyl)propan-2-ol (1.0 g, 5.8 mmol) in 40 mL benzene was added 0.1 g of p-toluenesulfonic acid and the solution was heated to 60° C. TLC analysis showed disappearance of the starting material. After cooling, the solution was extracted with EtOAc, washed with saturated NaHCO3, dried over Na2SO4, filtered and the solvent was removed in vacuo. 1,2-difluoro-4-isopropenyl-benzene was obtained as a yellow oil (0.82 g, 92% yield).

후처리

  1. temperatureAfter cooling
  2. extractionthe solution was extracted with EtOAc
  3. washwashed with saturated NaHCO3
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-68d80f066d674cbe92a06bae90410192
출처 데이터셋
uspto-grants-2003_09
특허 번호
US06620815B1

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